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Joined 2 years ago
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Cake day: July 6th, 2023

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  • The title of this press release implies causation, but the data only shows association.

    This is something the writer clearly understands, with the below comment

    Additionally, the report emphasizes a bidirectional relationship. “More than 40% of those with cardiovascular disease also have a mental health condition,” adds Vaccarino.

    So we have a strong association, but we don’t know the cause. So it’s possible that having cardiovascular risk, could cause mental illness. The reverse of the title implication

    Well I appreciate a press office isn’t the most nuanced of commentators, they should at least make a call towards better metabolic health as the takeaway.




  • Is it possible to never go to a fast food chain?

    We have the physical addiction to glucose, but you have overcome that before

    We have the habitual triggers, something in your life makes you think of your old addiction, those you have to find a way to get past, maybe the snacking

    We have the situational triggers, seeing a place, going past a place, triggers old addictive cravings, this is where having a buddy you can call and talk it out can be helpful.

    If you are willing to wear a CGM all the time, you can have a buddy monitoring it and get alerts if it goes outside of a predefined range (say 6.5) so your buddy can help you deal with the recovery

    When you fall off the wagon before, you mentioned fast food, but what is different the month before falling off and the day you fall off?



  • Maybe a accountability buddy who can see your CGM data in real time can help?

    Strategies I’ve found to get over cravings:

    • Stuff my face with a safe food like cheese, eggs, butter (yes, really)
    • Having my personal trainer get my CGM data
    • Tell myself I can cheat but only if I eat a can of tuna and 100g of cheese first
    • Set small multi-day goals, I’m just going to stay clean for 3 days in a row
    • Removing all illegal food from my house
    • Staying at a friends house where I don’t have the familiar triggers
    • Only allowing myself to cheat if my blood glucose is <5.0 and I eat the cheese first.

    What do you find helps you?


  • According to a book I am reading, diet science currently agrees that there is one way to loose weight: A calorie deficit.

    Not actually true, broadly true, but not actually true.

    For example, if I need 2000 kcal a day and eat only 1500 kcal a day, I will loose some weight over the next weeks/months.

    I strongly recommend not doing a blind calorie deficit for body composition purposes. This non-fasting deficiency will reduce your resulting metabolic rate.

    Calories are basically measured by burning food and measuring how much energy was set free.

    Calories are measured by exploding items in a bomb Calorimeter and measuring the photons produced. This is a mechanical apparatus that tells us about combustion, but is not the human digestion system (there are real differences). For instance wood has amazing calorie density but doesn’t do much for you as a human if you eat it.

    My question is: Why and how does it work so good and why are calories interchangeable?

    It broadly works in that if your burning X calories per day but only supplying X-500 calories the deficiency will need to be mobilized from your stored fat (ideally), but the body can also solve this little math equation by reducing your metabolic rate reducing the burn, it certainly will increase your hunger and cravings.

    Calories are 100% NOT interchangeable.

    They key is that thermodynamics applies to closed systems without mass transfers. Humans are open systems that do mass transfers all the time pooping, eating, drinking, peeing, breathing (carbon, oxygen, water vapor), and while humans don’t violate the laws of thermodynamics it is nearly impossible to isolate the system to meaningfully

    The far more clinically relevant viewpoint is the [Paper] The Carbohydrate-Insulin Model of Obesity - Beyond “Calories In, Calories Out” - 2018

    Fat burning, requires the absence of insulin in the blood. People using CICO for weight control are entering a low insulin state between meals, when they sleep, etc. Any time carbohydrates are consumed, blood glucose rises, raising insulin - when insulin is elevated the body will not mobilize fat from adipose tissue, i.e. it pauses fat burning. So someone eating the standard 3 meals and 3 snacks with carbs is pausing their fat burning 6 times per day (for 2-4 hours per eating session depending on their inherit insulin resistance) - Which is almost the entire day.

    This means a calorie from carbohydrates pauses fat burning for 2-4 hours, but a calorie from fat or protein does not. A calorie is not a calorie.

    Why is there no difference (concerning weight loss), if I eat 1500 calories as pure sugar or eat them as pure protein (where I would assume the body needs more energy to break down the protein)?

    There is a huge difference, as detailed above, the 1500 calories of sugar pauses the fat burning, the 1500 calories of protein does not. At the end of a day of eating sugar you will have less time actually burning stored fat.

    The downvotes I get when I talk about the limitations of the CICO rule of thumb show how appealing it is to people, but the reality of the human system is rooted in hormones and they can’t be ignored.


    It is possible to burn fat while consuming more then 1500 calories per day, body recomposition is documented in case studies of hyper caloric diets… this only works because of the insulin hormonal model.



  • That is a ton of misinformation

    Actually it’s really solid advice and lines up with my reading.

    Starting off with stating that bread and other grain are only simple carbohydrates when whole grains are an easy source of complex carbs.

    It really doesn’t matter, complex or simple all carbohydrates get turned into blood glucose, the only difference is a 15m onset delay. Blood glucose is blood glucose, if you want to fight cravings and low energy, you want to keep it low and even.

    And while sugar can be addictive it’s literally a nutrient that our body needs and if we fail to eat it, our body will just break down protein to produce it

    We absolutely do not need to eat sugar, the body will produce the tiny amount of glucose required via gluconeogenesis, when someone is fat adapted the vast majority of the body will run on fat, reducing the need for any glucose at all (only red blood cells, and 3-5% of the brain will still require glucose)

    Then while fats may by a good source of energy (because they offer 9 calories per gram) they are also an easy way to over consume calories because they are so dense.

    Fat is very satiating, it is VERY difficult to overeat fat in the absence of sugar. As a example think about eating a stick of butter by itself, that would be a difficult task if your not very hungry indeed.

    Saturated fats are still problematic and try and look for some articles published outside of the U.S.

    https://www.dietdoctor.com/low-carb/saturated-fat#evidence-to-date

    Saturated fat has been pilloried unfairly by the lipid heart hypothesis which is based on fabricated data. It’s vilification does not stand up to modern scrutiny. Basically fat is good for you.

    Then you start talking about vegetable oils being bad when olive oil has been the gold standard for healthy oil. There has been a ton of misinformation going around about seed oils trying to make them into the devil but again look for some RFK free Studies

    Industrial oils are examples of extremely processed foods which have many downsides, causing whole body inflammation, interfering with cholesterol rafts, artificially lowering lipoproteins (this is a bad thing). It’s true real authentic olive oil can be produced without heavy processing and avoids these issues, but it’s nearly impossible to source genuine olive oil, it is almost always adulterated with cheaper industrial oils (vegetable oils).

    There is no nutritional requirement in human health for industrial oils, they provide nothing essential, it is more prudent to eat real animal fats instead of fats from a chemical factory.


  • this time around i’ve been off the wagon long enough for those health metrics to show a significant decline and that coupled with both the general shitty feeling and the tariffs are pushing me back onto the wagon. i wish someone had advice to share with me on this.

    Doing a ketogenic eating pattern allows for the soups and stews and provides the energy. Without the sugar triggers in the daily diet it is easier to stay on the wagon long term. I also find using a CGM to get back on the wagon super helpful, seeing immediate feedback about blood glucose keeps the diet on track.






  • I’ve always been on the fringes, as a child even, hard science fiction with nobody to discuss with. Making your own decisions based on the best data, changing my mind on data, but not consensus, this were the early memories in my life. The great hard core scifi authors echo this message over and over, really hammer it in.

    While these may not be losing causes, they are not mainstream… and in relaxed wisdom of years I realize not being mainstream doesn’t mean wrong, but nobody is incentivized to push them. All we know of human history is what survived in writings scattered around, lucky enough to survive the ravages of time… being the crazy guy who writes everything down, makes copies of all their books, has two libraries in different locations… wasn’t a popular choice I’m sure, but it was the choice that survived.

    Open Source - This is intensely popular, not by sales, but by what survives and gets used for decades. The perfect algorithm locked in a dusty cabinet doesn’t advance humanity long term, imperfect open source that echos forward because its open and free does… This is why i think the permissive licenses are for software that will have the biggest impact.

    Ketogenic - Very unpopular, fringe and rejected by traditional consensus, but the benefits are actually there.

    Lemmy - It’s not a losing cause, its just got low marketing… its the only way for open communication to last into the future. If it ain’t federated it might as well be written in the sand.


  • I was pushed into a whole food plant based diet because it turns out I am genetically predisposed to coronary disease and absurdly high levels of cholesterol, arterial plaque, and inflammation. Built to run hard and die young, and I’m all out of young.

    Have you been keeping a eye on atherosclerosis with imaging like CAC scores?