The researchers discovered that once a tattoo is made, the ink rapidly travels through the lymphatic system and, within hours, accumulates in large quantities in the lymph nodes — key organs of the body’s defense system. Inside these nodes, immune cells called macrophages actively capture all types of pigment. This ink uptake triggers an inflammatory response with two phases: an acute phase lasting about two days after tattooing, followed by a chronic phase that can persist for years. The chronic phase is particularly concerning because it weakens the immune system, potentially increasing the susceptibility to infections and cancer. The study also showed that macrophages cannot break down the ink like they would other pathogens, wich causes them to die, especially with red and black inks, suggesting these colors may be more toxic. As a result, ink remains trapped in the lymph nodes in a continuous cycle of capture and cell death, gradually affecting the immune system’s defensive capacity.
The study found that tattooed mice produced significantly lower levels of antibodies after vaccination. This effect is likely due to the impaired function of immune cells that remain associated with tattoo ink for long periods. Similarly, human immune cells previously exposed to ink also showed a weakened response to vaccination.



Thanks for chiming in, but I’m not sure I understand the implications. It’s not trustworthy ? I shouldn’t listen to the conclusions ?
The implications are the variables are conflated and the conclusions are overblown.
It should come as no surprise that acute trauma and injecting a foreign substance would cause a relatively significant immunological response. The issue is that for the “chronic phase”, which is where the novelty of this research lies, the evidence shown is far from difinitive compared to the story being told and what results are shown aren’t overly significant.
Even if you 100% believe the paper the conclusion is that the effect of getting tattooed is, arguably, similar to catching the flu once. However, the paper itself tried to obfuscate that so they have a more impactful result and the marketing/outreach/media site that was linked here doubles down on it trying to sell the story of “tattoos==illness and death”!!!
Ok, I understand. Thanks for providing clarity