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fossilesque@mander.xyzM to Science@mander.xyzEnglish · 2 months ago

Psilocybin delays aging, extends lifespan, new Emory study suggests | Emory University | Atlanta GA

news.emory.edu

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Psilocybin delays aging, extends lifespan, new Emory study suggests | Emory University | Atlanta GA

news.emory.edu

fossilesque@mander.xyzM to Science@mander.xyzEnglish · 2 months ago
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Emory University researchers identified that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, actively delays aging in cells and organisms.
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  • Riddick3001@lemmy.world
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    2 months ago

    We should live in Shroom world, everybody will be connected by the mycelium, live long and prosper together.

    • NaibofTabr@infosec.pub
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      Yes… let the cordyceps eat your brain… become one with the omnifungi… let our will become yours… listen to the mold as it whispers in your mind…

      • Mac@mander.xyz
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        🤷‍♂️

        Okay, sure, why not

      • Vanilla_PuddinFudge@infosec.pub
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        2 months ago

        Eh, beats fascism.

      • steal_your_face@lemmy.ml
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        2 months ago

        I am the Globglogabgalab

      • lb_o@lemmy.world
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        2 months ago

        WE ARE THE ONE!

      • Øπ3ŕ@lemmy.dbzer0.com
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        2 months ago

        Did you drop this? /s

        You’re making it sound pretty damn amazing, frankly. Have you looked around lately? 😅😶‍🌫️

      • Mac@mander.xyz
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        2 months ago

        edit: double post

    • redchert@lemmygrad.ml
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      2 months ago

      There is already fungi that grows in your throat. Humans are connected to the mycelium - the most advanced lifeform on this planet.

  • jeffw@lemmy.world
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    2 months ago

    Forgive me for doubting any studies that don’t involve blinded trials… but this is just one study. Let’s see if it can be replicated before we get excited

    • remotelove@lemmy.ca
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      2 months ago

      Oh, I am going to try to replicate this study. I’ll hit you back in about 50 years if it worked.

      • jeffw@lemmy.world
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        2 months ago

        It takes you 50 years to transform into a mouse?

        • remotelove@lemmy.ca
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          2 months ago

          Or sooner, once the medicine kicks in.

          • jeffw@lemmy.world
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            2 months ago

            Whoa. You’re a mouse now?

  • BodyBySisyphus [he/him]@hexbear.net
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    2 months ago

    Results indicated that the mice that received an initial low dose of psilocybin of 5 mg/kg, followed by a monthly high dose of 15 mg/kg for 10 months, had a 30% increase in survival compared to mice who hadn’t received any.

    So if we take a standard 80 kg adult male, 80 * 15 mg = 1.2 g, which sources indicate is enough for a standard trip. That’s also like almost half an ounce of dried mushrooms. Time to start tripping… for science.

    • HootinNHollerin@lemmy.dbzer0.com
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      2 months ago

      1 oz is 28.35 g

      • BodyBySisyphus [he/him]@hexbear.net
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        2 months ago

        Yeah, the paper is talking about pure Psilocybin. I double checked and the rule of thumb is around 1% psilocybin by dry weight so I was actually off and you’d need closer to three ounces.

        • Castor_Troy [comrade/them,he/him]@hexbear.net
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          2 months ago

          (15 mg psilocybin / 1 kg body weight) * 80 kg body weight = 1200 mg psilocybin

          1200 mg psilocybin * (1 g psilocybin / 100 g dried mushrooms) = 12 g dried mushrooms

          I think it’s 12 grams dried mushrooms, which is almost half an ounce, like you first said.

          • Maturin [any]@hexbear.net
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            2 months ago

            Shouldn’t it be 1200 mg / 0.01 = 120 g of dried mushrooms?

            • Castor_Troy [comrade/them,he/him]@hexbear.net
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              2 months ago

              (15 mg psilocybin / 1 kg body weight) * 80 kg body weight = 1200 mg psilocybin

              1200 mg psilocybin = 1.2 g psilocybin * (100 g dried mushrooms / 1 g psilocybin) = 120 g dried mushrooms

              There we go.

            • Castor_Troy [comrade/them,he/him]@hexbear.net
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              2 months ago

              Thank you. I was staring at it and knew the units weren’t canceling out. That’s an insane dose though.

              • Maturin [any]@hexbear.net
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                2 months ago

                Even the “low dose” is the equivalent of almost 2 oz per dose. Those mice got to convene with the mice gods on the reg I’m sure.

                • propter_hog [any, any]@hexbear.net
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                  2 months ago

                  Boofing a whole tray of penis envy shrooms… for science

  • Laser@feddit.org
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    2 months ago

    A newly published study in Nature Partner Journals’ Aging demonstrates that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms,

    Maybe my memory is wrong, but I had it the other way around: Psilocin is the active substance, but its not very stable. Psilocybin gets metabolized to Psilocin. Calling it a “byproduct” is kind of underselling it. Psilocybin itself isn’t active by itself.

    Quick wiki check confirms this. I always have troubles with articles opening with. I can’t even read that as unfortunate wording.

  • Torn Apart By Dogs@lemmy.blahaj.zone
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    2 months ago

    HOLY SHIT IM GONNA LIVE FOREVER

  • ogmios@sh.itjust.works
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    deleted by creator

    • BurgerBaron@piefed.social
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      2 months ago

      You’d have to microdose regularly for it to matter if it actually does anything in humans for our telomeres.

      • ogmios@sh.itjust.works
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        deleted by creator

        • BurgerBaron@piefed.social
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          2 months ago

          Your sarcasm is noted, but seems daft when you suggest you’ll live longer because you ate a funny mushroom a couple times.

          • ogmios@sh.itjust.works
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            deleted by creator

  • wideopenarms [he/him]@hexbear.net
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    2 months ago

    Idc, I’ll just die old, no one’s ever gonna get me to willingly take hallucinogens

    Go ahead and hit me with the downbear, don’t care if that’s an L take or not

    • isolatedscotch@discuss.tchncs.de
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      2 months ago

      no healthy adult should feel the need to take any drug

      • Rivalarrival@lemmy.today
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        Need? Of course not. Desire? Certainly.

    • Øπ3ŕ@lemmy.dbzer0.com
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      You do you. Have fun!

  • Bronzebeard@lemmy.zip
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    2 months ago

    Nuh uh. I’ve seen the Last of US. We all know where this ends up

  • Hirom@beehaw.org
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    Wake me up when once there are results of a well-designed clinical trial.

    My understanding of the article is they’re extrapolating from experiments on mice and on a few human cells in a lab.

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